Research Articles:
Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena JF, Keefe MG, Escoubas CC, Dorman LC, Vainchtein ID, Chiaranunt P, Kotas ME, Nowakowski TJ, Bender KJ, Molofsky AB#, Molofsky AV.# Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior. Science. 2024 Nov;386(6721). PMID: 39480923. #co-corresponding
Mroz NM*, Ciesielska A*, Ewing-Crystal NA, Dorman LC, Han RT, Barron JJ, Silva NJ, Molofsky AV, Molofsky AB#, Paz JT#. Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury. bioRxiv. 2024 Dec 28;. doi: 10.1101/2024.12.28.630606. PubMed PMID: 39763918; PMC11703260. #co-corresponding
Ewing-Crystal, N.A., Mroz, N.M., Chang, A.A., Merrill, E.D., Caryotakis, S.E., Teo, L., Larpthaveesarp, A., Tsukui, T., Katewa, A., Pennington, R…. (2024). Dynamic fibroblast-immune interactions shape wound healing after brain injury. BioRxiv 1, 2024.03.13.584873.
Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK, Kaminskaya E, Nakao-Inoue H, Schwer B, Arnold TD, Molofsky AB, Condello C, Andino R, Nowakowski TJ, Molofsky AV. Type-I-interferon-responsive microglia shape cortical development and behavior. Cell. 2024 Apr 11;187(8):1936-1954.e24. PMC11015974.
Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. PMID: 37163060; PMC10168323.
Molofsky AB, Locksley RM. (2023) The ins and outs of innate and adaptive type 2 immunity Immunity, 56(4):704-722, PMCID: PMC10120575.
Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB# and Peng T* (2023) Dysregulated tissue niche potentiates resident lymphocytes to suppress an interferon-sensitive stem cell reservoir in emphysema. Immunity, 56(3):576-591, PMCID 10578134. * co-corresponding
Siewiera J, McIntyre T, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A. (2023). Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity. Immunity, 56(3):606-619. PMCID 10023352.
Han RT, Vainchtein ID, Schlachetzki, JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV. (2022). Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice. J. Exp. Med. 220 (2). PMCID PMC9757845.
Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. (2022) Immunity 2022;55(2):254-271.e7. PMID: 35139352
Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky AB, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. (2022). Sentinel p16-INK4a+ cells in the basement membrane form a reparative niche in the lung. Science 378(6616):192-201. PMCID 36227993.
O’Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang H-E, Schroeder AW, de Tonorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM (2022). Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. PMCID: PMC9166270.
Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD (2021). Early-life inflammation primes a T helper 2 cell–fibroblast niche in skin. Nature;599(7886):667–672.
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. 2021. Regulatory t-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife 10, 1–17 (2021). PMCID: 34652270.
Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky A V. (2020) Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell;182(2):388-403.e15. PMID: 32615087
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. Gli1 + mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020;22(11):1295–1306. PMID: 33046884
Dahlgren MW*, Jones SW*, Cautivo KM, Dubinin A, Farhat S, Ortiz-Carpena JF, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. (2019). Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. Immunity, 2019, 50, 707-722.e6. *authors contributed equally
Cameron, G.J.M., Cautivo, K.M., Loering, S., Jiang, S.H., Deshpande, A. V., Foster, P.S., McKenzie, A.N.J., Molofsky, A.B., Hansbro, P.M., and Starkey, M.R. (2019). Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. Front. Immunol.
Ricardo-Gonzalez, R.R., Van Dyken, S.J., Schneider, C., Lee, J., Nussbaum, J.C., Liang, H.-E., Vaka, D., Eckalbar, W.L., Molofsky, A.B., Erle, D.J., Locksley, R.M. (2018). Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol 19, 1093–1099.
Vainchtein, I.D., Chin, G., Cho, F.S., Kelley, K.W., Miller, J.G., Chien, E.C., Liddelow, S.A., Nguyen, P.T., Nakao-Inoue, H., Dorman, L.C., Akil, O., Joshita, S., Barres, B.A., Paz, J.T., Molofsky, A.B.*, Molofsky, A.V.* (2018). Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science, 85, eaal3589–9. *Co-corresponding
Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Halliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM (2016). A tissue checkpoint regulates type 2 immunity. Nat Immunol. 12m 1381-1387.
Molofsky, A.B., Van Gool, F., Liang, H.-E., Van Dyken, S.J., Nussbaum, J.C., Lee, J., Bluestone, J.A., and Locksley, R.M. (2015). Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity 43, 1-14.
Lee, M.-W., Odegaard, J.I., Mukundan, L., Qiu, Y., Molofsky, A.B., Nussbaum, J.C., Yun, K., Locksley, R.M., and Chawla, A. (2015). Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74–87.
Van Gool, F.*, Molofsky, A.B.*, Morar, M.M., Rosenzwajg, M., Liang, H.-E., Klatzmann, D., Locksley, R.M., and Bluestone, J.A. (2014). Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood 124, 3572–3576. *authors contributed equally
Dawson, A.L., LeBoit, P.E., Molofsky, A.B., Ai, W.Z., and Pincus, L.B. (2014). Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma. Pathology Case Reviews 19, 221–226.
Van Dyken, S. J. Mohapatra, A., Nussbaum, J.C., Molofsky, A.B., Thornton, E.E., Ziegler, S.F., McKenzie, A.N., Krummel, M.F., Liang, H.E., Locksley, R.M. (2014). Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity 40, 414–424.
Nussbaum J.C., Van Dyken S.J., Von Moltke J, Cheng L.E., Mohapatra A., Molofsky A.B., Thornton E.E., Krummel M.F., Chawla A., Liang H.E., Locksley R.M. (2013). Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502, 245–248.
Molofsky, A. B., Nussbaum, J. C., Liang, H.-E., Van Dyken, S. J., Cheng, L. E., Mohapatra, A., Chawla, A., Locksley R.M. (2013). Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. Journal of Experimental Medicine, 210(3), 535–549.
Rollins, M. D., Molofsky, A. B., Nambiar, A., Pandey, S., Weiskopf, R. B., & Toy, P. (2012). Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Critical care medicine, 40(8), 2488–2491.
Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-Gonzalez, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., Locksley, R.M. (2011). Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 332(6026), 243–247.
Molofsky, A. B., Byrne, B. G., Whitfield, N. N., Madigan, C. A., Fuse, E. T., Tateda, K., & Swanson, M. S. (2006). Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. The Journal of experimental medicine, 203(4), 1093–1104.
Molofsky, A. B., Shetron-Rama, L. M., & Swanson, M. S. (2005). Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infection and immunity, 73(9), 5720–5734.
Molofsky, A. B., & Swanson, M. S. (2003). Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication. Mol Microbiol, 50(2), 445–461.
Patterson, K., Molofsky, A. B., Robinson, C., Acosta, S., Cater, C., & Fischer, J. A. (2004). The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. Molecular biology of the cell, 15(2), 600–610.
Review articles and Book chapters:
Ricardo-gonzalez RR, Molofsky AB, Locksley RM. ILC2s – development , divergence , dispersal. Curr Opin Immunol; 2022;1–7.
Sbierski-Kind, J., Mroz, N. & Molofsky, A. B., 2021. Perivascular stromal cells: Directors of tissue immune niches. Immunol. Rev. 302, 10–31.
Cautivo, K.M., Steer, C.A., Molofsky, A.B., 2020. Immune outposts in the adventitia: One foot in sea and one on shore. Curr Opin Immunol. 64, 34-41.
Molofsky, A. B. & Locksley, R. M. (2020) Tissue immunity broadcasts near and far. Nat. Rev. Immunol. 20, 93–94.
Dahlgren, M.W., Molofsky, A.B., 2019. Adventitial Cuffs: Regional Hubs for Tissue Immunity. Trends Immunol. 40, 877-887.
Dahlgren, M.W., Molofsky, A.B., 2018. All along the watchtower: group 2 innate lymphoid cells in allergic responses. Curr Opin Immunol. 54, 13–19.
Cautivo, K.M., Molofsky, A.B. (2016). Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells. Eur. J. Immunol. 1–31.
Guigas, B., Molofsky, A.B. (2015). A worm of one's own: how helminths modulate host adipose tissue function and metabolism. Trends Parasitol. 31, 435–441.
Molofsky, A.B., Savage, A.K., and Locksley, R.M. (2015). Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity 42, 1005–1019.
Molofsky, A.B. and Siddiqi, I.N. (2011). Case studies in hematology and coagulation: a new ASCP case set. Book chapter contributors for “Chronic myelogenous leukemia” and “Chronic neutrophilic leukemia”, Gulati, G., Flicko-O’Hara, J., and Krause, J.R. eds, American Society of Clinical Pathology.
Molofsky A.B. and Lu C.M. (2009). Anaplastic Large Cell Lymphoma, Anaplastic Lymphoma Kinase-Positive (ALCL, ALK+). Check Sample, Hematology, American Society of Clinical Pathology.
Swanson M.S., Byrne B.G., Whitfield N.W., Fuse E.T., Tateda K., and Molofsky A.B. (2006). An inflammatory immune response to cytosolic flagellin protects mice from L. pneumophilainfection. Book Chapter in Legionella- Proceedings of the 6th International Conference, Cianciotto, N. et al., eds., ASM Press, Washington DC.
Swanson M.S. and Molofsky A.B. (2005). Autophagy and Inflammatory Cell Death, Partners of Innate Immunity. Review, Autophagy 1(3), 174-6.
Molofsky, A.B., and Swanson, M.S. (2004). Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol 53, 29–40.r